Drug interactions
Letermovir + Sertraline
Severity: Minor
Letermovir and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and may modestly increase exposure to CYP3A substrates, but it can also induce CYP2C9 and CYP2C19. Sertraline is cleared by several pathways, so the net effect is probably small and variable.
What this interaction means in plain words
Letermovir and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Sertraline belongs to Central Nervous System.
Why it happens
Letermovir inhibits CYP3A4 and induces CYP2C19/CYP2C9, with an uncertain net effect on sertraline clearance.
What to do
Monitor antidepressant response and tolerability when letermovir is started or stopped; adjust the sertraline dose only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Sertraline?
MediHelp rates the interaction as minor. Letermovir and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits CYP3A4 and may modestly increase exposure to CYP3A substrates, but it can also induce CYP2C9 and CYP2C19. Sertraline is cleared by several pathways, so the net effect is probably small and variable.
How serious is the interaction between Letermovir and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and tolerability when letermovir is started or stopped; adjust the sertraline dose only if needed.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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