Drug interactions
Leuprolide + Lumefantrine
Severity: Major
Leuprolide and Lumefantrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine can prolong the QT interval, and androgen deprivation with leuprolide may add to this. Together they increase the risk of torsades de pointes.
What this interaction means in plain words
Leuprolide and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation from androgen deprivation (leuprolide) and delayed repolarization (lumefantrine).
What to do
Check a baseline ECG and correct potassium and magnesium. Monitor the QTc during treatment, or use an alternative antimalarial if the QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Lumefantrine?
MediHelp rates the interaction as major. Leuprolide and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumefantrine can prolong the QT interval, and androgen deprivation with leuprolide may add to this. Together they increase the risk of torsades de pointes.
How serious is the interaction between Leuprolide and Lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium. Monitor the QTc during treatment, or use an alternative antimalarial if the QTc is prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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