Drug interactions
Dofetilide + Leuprolide
Severity: Major
Dofetilide and Leuprolide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide causes dose-dependent QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to this effect. The combination increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Dofetilide and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation: dofetilide blocks the IKr potassium current, and androgen deprivation may prolong repolarization.
What to do
Avoid the combination where possible. If both are required, monitor the ECG and QTc closely, keep potassium and magnesium normal, and adjust the dofetilide dose according to the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Leuprolide?
MediHelp rates the interaction as major. Dofetilide and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide causes dose-dependent QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to this effect. The combination increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Dofetilide and Leuprolide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, monitor the ECG and QTc closely, keep potassium and magnesium normal, and adjust the dofetilide dose according to the QTc.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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