Drug interactions
Levetiracetam + Perphenazine
Severity: Moderate
Levetiracetam and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and impaired concentration, so combined use may increase sedation. Phenothiazines may also lower the seizure threshold, which could oppose the anticonvulsant effect of levetiracetam.
What this interaction means in plain words
Levetiracetam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression; perphenazine may lower the seizure threshold.
What to do
Monitor for oversedation and for any change in seizure frequency. Counsel patients about driving and machinery until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Perphenazine?
MediHelp rates the interaction as moderate. Levetiracetam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, dizziness and impaired concentration, so combined use may increase sedation. Phenothiazines may also lower the seizure threshold, which could oppose the anticonvulsant effect of levetiracetam.
How serious is the interaction between Levetiracetam and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and for any change in seizure frequency. Counsel patients about driving and machinery until the response is known.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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