Drug interactions
Levetiracetam + Temazepam
Severity: Moderate
Levetiracetam and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic that causes sedation and psychomotor impairment. Levetiracetam may increase drowsiness and dizziness, raising the risk of falls and next-day impairment.
What this interaction means in plain words
Levetiracetam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Use the lowest effective temazepam dose and monitor for daytime sedation and falls, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Levetiracetam with Temazepam?
MediHelp rates the interaction as moderate. Levetiracetam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is a benzodiazepine hypnotic that causes sedation and psychomotor impairment. Levetiracetam may increase drowsiness and dizziness, raising the risk of falls and next-day impairment.
How serious is the interaction between Levetiracetam and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose and monitor for daytime sedation and falls, especially in older adults.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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