Drug interactions
Levetiracetam + Tizanidine
Severity: Moderate
Levetiracetam and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam commonly causes somnolence, asthenia and dizziness, and tizanidine adds sedation, so the combination may reduce alertness and coordination. The effect is typically manageable.
What this interaction means in plain words
Levetiracetam and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from central alpha-2 agonism and the CNS effects of levetiracetam.
What to do
Monitor for drowsiness and dizziness during initiation and titration, and counsel patients about driving. Reduce dose of either drug if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Tizanidine?
MediHelp rates the interaction as moderate. Levetiracetam and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levetiracetam commonly causes somnolence, asthenia and dizziness, and tizanidine adds sedation, so the combination may reduce alertness and coordination. The effect is typically manageable.
How serious is the interaction between Levetiracetam and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness during initiation and titration, and counsel patients about driving. Reduce dose of either drug if impairment occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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