Drug interactions
Levetiracetam + Ziconotide
Severity: Moderate
Levetiracetam and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide given intrathecally commonly causes dizziness, confusion, somnolence and reduced consciousness. Levetiracetam can add to sedation and cognitive impairment.
What this interaction means in plain words
Levetiracetam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects; no pharmacokinetic interaction is established.
What to do
Monitor mental status and level of alertness, particularly during ziconotide titration. Reduce or stop ziconotide if significant cognitive impairment or decreased consciousness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Levetiracetam with Ziconotide?
MediHelp rates the interaction as moderate. Levetiracetam and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide given intrathecally commonly causes dizziness, confusion, somnolence and reduced consciousness. Levetiracetam can add to sedation and cognitive impairment.
How serious is the interaction between Levetiracetam and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and level of alertness, particularly during ziconotide titration. Reduce or stop ziconotide if significant cognitive impairment or decreased consciousness develops.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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