Drug interactions
Levocetirizine + Midazolam
Severity: Minor
Levocetirizine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levocetirizine is a minimally sedating antihistamine, but it can still cause somnolence in some patients. Combined with midazolam, additive drowsiness and psychomotor impairment may occur.
What this interaction means in plain words
Levocetirizine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levocetirizine belongs to Respiratory; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression; levocetirizine has limited central H1 receptor occupancy.
What to do
Monitor sedation after midazolam dosing and counsel patients to avoid driving or hazardous tasks until the effect is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Levocetirizine
Frequently asked questions
Can I take Levocetirizine with Midazolam?
MediHelp rates the interaction as minor. Levocetirizine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levocetirizine is a minimally sedating antihistamine, but it can still cause somnolence in some patients. Combined with midazolam, additive drowsiness and psychomotor impairment may occur.
How serious is the interaction between Levocetirizine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after midazolam dosing and counsel patients to avoid driving or hazardous tasks until the effect is known.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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