Drug interactions
Levodopa + Losartan
Severity: Moderate
Levodopa and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and combined with antihypertensives such as losartan may lead to symptomatic drops in blood pressure, especially on starting therapy or raising doses.
What this interaction means in plain words
Levodopa and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Losartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from levodopa-derived dopamine and angiotensin receptor blockade.
What to do
Monitor sitting and standing blood pressure when starting or adjusting either drug. Reduce the antihypertensive dose if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Losartan?
MediHelp rates the interaction as moderate. Levodopa and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and combined with antihypertensives such as losartan may lead to symptomatic drops in blood pressure, especially on starting therapy or raising doses.
How serious is the interaction between Levodopa and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure when starting or adjusting either drug. Reduce the antihypertensive dose if orthostatic symptoms occur.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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