Drug interactions
Levodopa + Lurasidone
Severity: Moderate
Levodopa and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks dopamine D2 receptors and can counteract the antiparkinsonian effect of levodopa, worsening motor symptoms. Additive orthostatic hypotension may also occur.
What this interaction means in plain words
Levodopa and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors, with additive hypotensive effects.
What to do
Monitor motor function and blood pressure, and use the lowest effective lurasidone dose. In Parkinson's disease, prefer an antipsychotic with less D2 blockade such as quetiapine or clozapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Lurasidone?
MediHelp rates the interaction as moderate. Levodopa and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks dopamine D2 receptors and can counteract the antiparkinsonian effect of levodopa, worsening motor symptoms. Additive orthostatic hypotension may also occur.
How serious is the interaction between Levodopa and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function and blood pressure, and use the lowest effective lurasidone dose. In Parkinson's disease, prefer an antipsychotic with less D2 blockade such as quetiapine or clozapine.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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