Drug interactions
Levodopa + Macimorelin
Severity: Moderate
Levodopa and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa influences growth hormone release and may alter the result of the macimorelin stimulation test, leading to misdiagnosis of growth hormone deficiency.
What this interaction means in plain words
Levodopa and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Levodopa stimulates growth hormone secretion, a pharmacodynamic effect that confounds the test.
What to do
Withhold levodopa for an adequate washout period before testing when clinically possible, or interpret results with caution.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Macimorelin
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Macimorelin?
MediHelp rates the interaction as moderate. Levodopa and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa influences growth hormone release and may alter the result of the macimorelin stimulation test, leading to misdiagnosis of growth hormone deficiency.
How serious is the interaction between Levodopa and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold levodopa for an adequate washout period before testing when clinically possible, or interpret results with caution.
What other medicines interact with Macimorelin?
MediHelp also lists interactions of Macimorelin with, for example, Alfuzosin, Amiodarone, Amisulpride. The full list is on the Macimorelin page.
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