Drug interactions
Levodopa + Metoprolol
Severity: Moderate
Levodopa and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure, and combining it with metoprolol may add to the hypotensive effect, particularly when treatment is started or doses are raised. Patients may experience dizziness, orthostatic hypotension or falls.
What this interaction means in plain words
Levodopa and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from levodopa-derived dopamine and beta-blockade.
What to do
Check supine and standing blood pressure when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic orthostatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Metoprolol?
MediHelp rates the interaction as moderate. Levodopa and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure, and combining it with metoprolol may add to the hypotensive effect, particularly when treatment is started or doses are raised. Patients may experience dizziness, orthostatic hypotension or falls.
How serious is the interaction between Levodopa and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check supine and standing blood pressure when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic orthostatic hypotension occurs.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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