Drug interactions
Levodopa + Midazolam
Severity: Moderate
Levodopa and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause somnolence and hypotension, and benzodiazepines may add to these effects. Benzodiazepines have also been reported to reduce the antiparkinsonian effect of levodopa in some patients.
What this interaction means in plain words
Levodopa and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive sedation and hypotension, with possible pharmacodynamic antagonism of levodopa's effect.
What to do
Monitor sedation, blood pressure and parkinsonian symptom control. Use the lowest effective midazolam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Midazolam?
MediHelp rates the interaction as moderate. Levodopa and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause somnolence and hypotension, and benzodiazepines may add to these effects. Benzodiazepines have also been reported to reduce the antiparkinsonian effect of levodopa in some patients.
How serious is the interaction between Levodopa and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and parkinsonian symptom control. Use the lowest effective midazolam dose.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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