Drug interactions
Levodopa + Solifenacin
Severity: Minor
Levodopa and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antimuscarinics can add to the effect of levodopa on parkinsonian tremor, but may also worsen dyskinesia. Slowed gastric emptying can reduce levodopa absorption, and anticholinergic effects such as confusion may be additive in older patients.
What this interaction means in plain words
Levodopa and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levodopa belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Pharmacodynamic anticholinergic and dopaminergic opposition, plus delayed gastric emptying that may reduce levodopa absorption.
What to do
Monitor motor response, dyskinesia and cognition when starting solifenacin. Adjust the levodopa dose if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Solifenacin?
MediHelp rates the interaction as minor. Levodopa and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antimuscarinics can add to the effect of levodopa on parkinsonian tremor, but may also worsen dyskinesia. Slowed gastric emptying can reduce levodopa absorption, and anticholinergic effects such as confusion may be additive in older patients.
How serious is the interaction between Levodopa and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor response, dyskinesia and cognition when starting solifenacin. Adjust the levodopa dose if the response changes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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