Drug interactions
Levofloxacin + Macimorelin
Severity: Major
Levofloxacin and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a modest QT prolongation, and levofloxacin may add to it. This could raise the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Levofloxacin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levofloxacin belongs to Anti Bacterial; Macimorelin belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Avoid giving macimorelin to patients taking levofloxacin. Postpone the test until levofloxacin has been stopped for a sufficient washout period.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Levofloxacin with Macimorelin?
MediHelp rates the interaction as major. Levofloxacin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a modest QT prolongation, and levofloxacin may add to it. This could raise the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Levofloxacin and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking levofloxacin. Postpone the test until levofloxacin has been stopped for a sufficient washout period.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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