Drug interactions
Levofloxacin + Nabumetone
Severity: Moderate
Levofloxacin and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can lower the seizure threshold, and NSAIDs may add to this effect. Seizures are rare but can be serious, especially in patients with epilepsy, prior CNS disease or renal impairment.
What this interaction means in plain words
Levofloxacin and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Nabumetone belongs to Musculoskeletal.
Why it happens
Fluoroquinolones antagonise GABA-A receptor inhibition, and NSAIDs may potentiate this effect, producing additive CNS excitation.
What to do
Avoid the combination in patients with a seizure history or other predisposing factors. If it is used, counsel the patient to report tremor, confusion or twitching and stop the fluoroquinolone if neurological symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Nabumetone?
MediHelp rates the interaction as moderate. Levofloxacin and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can lower the seizure threshold, and NSAIDs may add to this effect. Seizures are rare but can be serious, especially in patients with epilepsy, prior CNS disease or renal impairment.
How serious is the interaction between Levofloxacin and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other predisposing factors. If it is used, counsel the patient to report tremor, confusion or twitching and stop the fluoroquinolone if neurological symptoms appear.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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