Drug interactions
Levofloxacin + Osimertinib
Severity: Moderate
Levofloxacin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and levofloxacin has a known QT-prolonging effect. The combination may increase the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Levofloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform periodic ECG and electrolyte monitoring and correct potassium and magnesium abnormalities. Prefer a non-QT-prolonging antibiotic, and withhold or reduce osimertinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Levofloxacin with Osimertinib?
MediHelp rates the interaction as moderate. Levofloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, and levofloxacin has a known QT-prolonging effect. The combination may increase the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Levofloxacin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring and correct potassium and magnesium abnormalities. Prefer a non-QT-prolonging antibiotic, and withhold or reduce osimertinib if QTc becomes markedly prolonged.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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