Drug interactions
Levofloxacin + Oxaliplatin
Severity: Moderate
Levofloxacin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and levofloxacin can add to this effect. The combination increases arrhythmia risk, especially with electrolyte disturbances from chemotherapy.
What this interaction means in plain words
Levofloxacin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Monitor ECG and correct potassium and magnesium before and during therapy. Consider a non-QT-prolonging antibiotic if the patient has other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Levofloxacin with Oxaliplatin?
MediHelp rates the interaction as moderate. Levofloxacin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and levofloxacin can add to this effect. The combination increases arrhythmia risk, especially with electrolyte disturbances from chemotherapy.
How serious is the interaction between Levofloxacin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during therapy. Consider a non-QT-prolonging antibiotic if the patient has other risk factors.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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