Drug interactions
Levofloxacin + Paliperidone
Severity: Moderate
Levofloxacin and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, increasing the potential for torsades de pointes. Risk rises with renal impairment, which raises paliperidone exposure, and with electrolyte disturbances.
What this interaction means in plain words
Levofloxacin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Paliperidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization through potassium channel blockade.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor the QTc, and consider an alternative antibiotic in patients with known QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Levofloxacin with Paliperidone?
MediHelp rates the interaction as moderate. Levofloxacin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, increasing the potential for torsades de pointes. Risk rises with renal impairment, which raises paliperidone exposure, and with electrolyte disturbances.
How serious is the interaction between Levofloxacin and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor the QTc, and consider an alternative antibiotic in patients with known QT risk.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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