Drug interactions
Levofloxacin + Piroxicam
Severity: Moderate
Levofloxacin and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones may increase the chance of CNS stimulation and convulsions, especially in patients with a seizure history or other predisposing factors. The risk is low in most patients.
What this interaction means in plain words
Levofloxacin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Piroxicam belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, which NSAIDs may potentiate, lowers seizure threshold.
What to do
Avoid the combination in patients with epilepsy or other seizure risk factors. Otherwise use the lowest effective doses and monitor for CNS symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Piroxicam?
MediHelp rates the interaction as moderate. Levofloxacin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs given with fluoroquinolones may increase the chance of CNS stimulation and convulsions, especially in patients with a seizure history or other predisposing factors. The risk is low in most patients.
How serious is the interaction between Levofloxacin and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with epilepsy or other seizure risk factors. Otherwise use the lowest effective doses and monitor for CNS symptoms.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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