Drug interactions
Levofloxacin + Rosiglitazone
Severity: Minor
Levofloxacin and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause dysglycemia, and glucose control may become unpredictable in patients taking antidiabetic drugs. Rosiglitazone alone rarely causes hypoglycemia, so the risk is mostly changed glycemic control.
What this interaction means in plain words
Levofloxacin and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levofloxacin belongs to Anti Bacterial; Rosiglitazone belongs to Endocrine.
Why it happens
Fluoroquinolone effects on insulin secretion may alter glucose homeostasis; the overlap with rosiglitazone is largely pharmacodynamic and theoretical.
What to do
Monitor blood glucose during levofloxacin therapy and counsel the patient on symptoms of glucose disturbance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levofloxacin and Rosiglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Levofloxacin with Rosiglitazone?
MediHelp rates the interaction as minor. Levofloxacin and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoroquinolones can cause dysglycemia, and glucose control may become unpredictable in patients taking antidiabetic drugs. Rosiglitazone alone rarely causes hypoglycemia, so the risk is mostly changed glycemic control.
How serious is the interaction between Levofloxacin and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during levofloxacin therapy and counsel the patient on symptoms of glucose disturbance.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
