Drug interactions
Levofloxacin + Selinexor
Severity: Moderate
Levofloxacin and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurologic effects, and fluoroquinolones can also cause CNS adverse effects. Concurrent use may add to these symptoms, though a direct interaction is not well characterized.
What this interaction means in plain words
Levofloxacin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Selinexor belongs to Oncology.
Why it happens
Possible additive CNS adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and falls and counsel the patient accordingly. Consider an alternative antibiotic if neurologic symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Levofloxacin with Selinexor?
MediHelp rates the interaction as moderate. Levofloxacin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurologic effects, and fluoroquinolones can also cause CNS adverse effects. Concurrent use may add to these symptoms, though a direct interaction is not well characterized.
How serious is the interaction between Levofloxacin and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and falls and counsel the patient accordingly. Consider an alternative antibiotic if neurologic symptoms worsen.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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