Drug interactions
Levofloxacin + Vemurafenib
Severity: Major
Levofloxacin and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib causes concentration-dependent QT prolongation, and levofloxacin has similar effects. Combined use increases the chance of torsades de pointes and other serious arrhythmias.
What this interaction means in plain words
Levofloxacin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levofloxacin belongs to Anti Bacterial; Vemurafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Prefer an antibiotic without QT effects. If it is unavoidable, monitor ECG and electrolytes and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Levofloxacin with Vemurafenib?
MediHelp rates the interaction as major. Levofloxacin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib causes concentration-dependent QT prolongation, and levofloxacin has similar effects. Combined use increases the chance of torsades de pointes and other serious arrhythmias.
How serious is the interaction between Levofloxacin and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic without QT effects. If it is unavoidable, monitor ECG and electrolytes and correct potassium and magnesium.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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