Drug interactions
Levofloxacin + Voriconazole
Severity: Moderate
Levofloxacin and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and used together they raise the risk of torsades de pointes. Risk is greater with hypokalemia, hypomagnesemia, bradycardia or other QT-prolonging drugs.
What this interaction means in plain words
Levofloxacin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Voriconazole belongs to Anti Fungals.
Why it happens
Additive inhibition of cardiac repolarizing potassium currents causing QT prolongation.
What to do
Get a baseline ECG and correct electrolytes before starting, with repeat ECG during co-treatment. Choose a non-QT-prolonging antibiotic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Levofloxacin with Voriconazole?
MediHelp rates the interaction as moderate. Levofloxacin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and used together they raise the risk of torsades de pointes. Risk is greater with hypokalemia, hypomagnesemia, bradycardia or other QT-prolonging drugs.
How serious is the interaction between Levofloxacin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Get a baseline ECG and correct electrolytes before starting, with repeat ECG during co-treatment. Choose a non-QT-prolonging antibiotic if the QTc becomes prolonged.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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