Drug interactions
Levofloxacin + Vorinostat
Severity: Moderate
Levofloxacin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined therapy may increase the risk of torsades de pointes. The risk is higher in oncology patients with electrolyte disturbances, vomiting, or other QT-prolonging medicines.
What this interaction means in plain words
Levofloxacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Vorinostat belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Check baseline ECG and potassium, magnesium and calcium, and repeat periodically during co-therapy. Consider a non-QT-prolonging antibiotic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Levofloxacin with Vorinostat?
MediHelp rates the interaction as moderate. Levofloxacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined therapy may increase the risk of torsades de pointes. The risk is higher in oncology patients with electrolyte disturbances, vomiting, or other QT-prolonging medicines.
How serious is the interaction between Levofloxacin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium, magnesium and calcium, and repeat periodically during co-therapy. Consider a non-QT-prolonging antibiotic where possible.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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