Drug interactions
Levoketoconazole + Levonorgestrel
Severity: Minor
Levoketoconazole and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can increase systemic levonorgestrel levels. With an intrauterine system the effect is small, but with oral levonorgestrel progestogenic adverse effects may increase.
What this interaction means in plain words
Levoketoconazole and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Levonorgestrel belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition by levoketoconazole reduces levonorgestrel clearance.
What to do
Usually no change is needed; monitor for progestogenic adverse effects if oral levonorgestrel is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Levonorgestrel?
MediHelp rates the interaction as minor. Levoketoconazole and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole is a strong CYP3A4 inhibitor and can increase systemic levonorgestrel levels. With an intrauterine system the effect is small, but with oral levonorgestrel progestogenic adverse effects may increase.
How serious is the interaction between Levoketoconazole and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; monitor for progestogenic adverse effects if oral levonorgestrel is used long term.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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