Drug interactions
Levoketoconazole + Meloxicam
Severity: Moderate
Levoketoconazole and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP3A4 and may inhibit CYP2C9 to some degree, so meloxicam concentrations could rise. Because meloxicam has multiple pathways the effect is likely modest, but higher exposure increases NSAID toxicity risk.
What this interaction means in plain words
Levoketoconazole and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Meloxicam belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9 and CYP3A4 metabolism of meloxicam.
What to do
Use the lowest effective meloxicam dose and monitor for GI bleeding, edema, and renal function changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Meloxicam?
MediHelp rates the interaction as moderate. Levoketoconazole and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP3A4 and may inhibit CYP2C9 to some degree, so meloxicam concentrations could rise. Because meloxicam has multiple pathways the effect is likely modest, but higher exposure increases NSAID toxicity risk.
How serious is the interaction between Levoketoconazole and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meloxicam dose and monitor for GI bleeding, edema, and renal function changes.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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