Drug interactions
Levoketoconazole + Metformin-pioglitazone
Severity: Moderate
Levoketoconazole and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP3A4 and may modestly increase pioglitazone exposure, although pioglitazone is mainly cleared by CYP2C8. Levoketoconazole itself can also lower glucose in Cushing's syndrome, and its hepatotoxicity may add to that of pioglitazone.
What this interaction means in plain words
Levoketoconazole and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP enzymes involved in pioglitazone metabolism, plus additive effects on glycemia and liver injury.
What to do
Monitor blood glucose and liver enzymes during coadministration, and adjust pioglitazone if hypoglycemia or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Levoketoconazole and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP3A4 and may modestly increase pioglitazone exposure, although pioglitazone is mainly cleared by CYP2C8. Levoketoconazole itself can also lower glucose in Cushing's syndrome, and its hepatotoxicity may add to that of pioglitazone.
How serious is the interaction between Levoketoconazole and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and liver enzymes during coadministration, and adjust pioglitazone if hypoglycemia or edema occurs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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