Drug interactions
Levoketoconazole + Nifedipine
Severity: Major
Levoketoconazole and Nifedipine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase nifedipine exposure. This may cause marked hypotension, tachycardia and edema.
What this interaction means in plain words
Levoketoconazole and Nifedipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levoketoconazole belongs to Endocrine; Nifedipine belongs to Cardiovascular.
Why it happens
Strong CYP3A4 inhibition reduces nifedipine first-pass and systemic metabolism.
What to do
Start nifedipine at a low dose and titrate carefully with blood pressure monitoring, or choose an alternative antihypertensive not metabolized by CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nifedipine
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Nifedipine?
MediHelp rates the interaction as major. Levoketoconazole and Nifedipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase nifedipine exposure. This may cause marked hypotension, tachycardia and edema.
How serious is the interaction between Levoketoconazole and Nifedipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nifedipine at a low dose and titrate carefully with blood pressure monitoring, or choose an alternative antihypertensive not metabolized by CYP3A4.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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