Drug interactions
Levoketoconazole + Oxybutynin
Severity: Moderate
Levoketoconazole and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can raise oxybutynin concentrations, particularly with the immediate-release oral form. This may increase anticholinergic adverse effects such as dry mouth, constipation, confusion and urinary retention.
What this interaction means in plain words
Levoketoconazole and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Oxybutynin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated intestinal and hepatic first-pass metabolism of oxybutynin.
What to do
Monitor for anticholinergic toxicity and consider a lower oxybutynin dose or an alternative agent if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Oxybutynin?
MediHelp rates the interaction as moderate. Levoketoconazole and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can raise oxybutynin concentrations, particularly with the immediate-release oral form. This may increase anticholinergic adverse effects such as dry mouth, constipation, confusion and urinary retention.
How serious is the interaction between Levoketoconazole and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider a lower oxybutynin dose or an alternative agent if adverse effects emerge.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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