Drug interactions
Levoketoconazole + Praziquantel
Severity: Moderate
Levoketoconazole and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, and ketoconazole is known to raise praziquantel levels. Higher exposure may increase dizziness, drowsiness and gastrointestinal effects.
What this interaction means in plain words
Levoketoconazole and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Praziquantel belongs to Anti Parasitic.
Why it happens
Levoketoconazole potently inhibits CYP3A4, decreasing first-pass and hepatic metabolism of praziquantel.
What to do
Monitor for praziquantel adverse effects and advise against driving after dosing. Consider whether treatment can be timed around the azole if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Praziquantel?
MediHelp rates the interaction as moderate. Levoketoconazole and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor, and ketoconazole is known to raise praziquantel levels. Higher exposure may increase dizziness, drowsiness and gastrointestinal effects.
How serious is the interaction between Levoketoconazole and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for praziquantel adverse effects and advise against driving after dosing. Consider whether treatment can be timed around the azole if clinically appropriate.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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