Drug interactions
Levoketoconazole + Prednisolone
Severity: Moderate
Levoketoconazole and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and also inhibits steroid synthesis. It can raise prednisolone exposure and enhance steroid effects, while also lowering endogenous cortisol, which complicates adrenal assessment.
What this interaction means in plain words
Levoketoconazole and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4 and P-glycoprotein, reducing prednisolone clearance.
What to do
Monitor for signs of corticosteroid excess and consider reducing the prednisolone dose. Watch for adrenal insufficiency with the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Prednisolone?
MediHelp rates the interaction as moderate. Levoketoconazole and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and also inhibits steroid synthesis. It can raise prednisolone exposure and enhance steroid effects, while also lowering endogenous cortisol, which complicates adrenal assessment.
How serious is the interaction between Levoketoconazole and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and consider reducing the prednisolone dose. Watch for adrenal insufficiency with the combination.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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