Drug interactions
Levoketoconazole + Sorafenib
Severity: Moderate
Levoketoconazole and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, but sorafenib is cleared by both CYP3A4 and UGT1A9, and strong inhibitors have not produced large increases in sorafenib exposure. Levoketoconazole also prolongs the QT interval, which sorafenib may add to.
What this interaction means in plain words
Levoketoconazole and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Sorafenib belongs to Oncology.
Why it happens
CYP3A4 inhibition by levoketoconazole and additive QT prolongation.
What to do
Monitor ECG and electrolytes, and watch for sorafenib toxicity. Reduce the sorafenib dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Sorafenib?
MediHelp rates the interaction as moderate. Levoketoconazole and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor, but sorafenib is cleared by both CYP3A4 and UGT1A9, and strong inhibitors have not produced large increases in sorafenib exposure. Levoketoconazole also prolongs the QT interval, which sorafenib may add to.
How serious is the interaction between Levoketoconazole and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for sorafenib toxicity. Reduce the sorafenib dose if adverse effects emerge.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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