Drug interactions
Levoketoconazole + Tobramycin
Severity: Minor
Levoketoconazole and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits P-glycoprotein in vitro, but tobramycin is eliminated almost entirely by glomerular filtration and is poorly absorbed orally. A clinically meaningful rise in tobramycin exposure is not established.
What this interaction means in plain words
Levoketoconazole and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Tobramycin belongs to Anti Bacterial.
Why it happens
Theoretical P-glycoprotein inhibition; the clinical relevance for tobramycin is not established.
What to do
No routine adjustment is needed; follow standard tobramycin serum level and renal function monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Tobramycin?
MediHelp rates the interaction as minor. Levoketoconazole and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole inhibits P-glycoprotein in vitro, but tobramycin is eliminated almost entirely by glomerular filtration and is poorly absorbed orally. A clinically meaningful rise in tobramycin exposure is not established.
How serious is the interaction between Levoketoconazole and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; follow standard tobramycin serum level and renal function monitoring.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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