Drug interactions
Levoketoconazole + Tretinoin
Severity: Moderate
Levoketoconazole and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP enzymes that metabolize tretinoin, which may raise systemic tretinoin levels and increase retinoid toxicity such as headache, pseudotumor cerebri and hypertriglyceridemia. Oral tretinoin is the main concern.
What this interaction means in plain words
Levoketoconazole and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Tretinoin belongs to Dermatology.
Why it happens
Levoketoconazole inhibits CYP-mediated (including CYP3A4 and CYP2C8) oxidative metabolism of tretinoin.
What to do
Monitor for retinoid toxicity and intracranial hypertension signs; consider reducing the tretinoin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Tretinoin?
MediHelp rates the interaction as moderate. Levoketoconazole and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP enzymes that metabolize tretinoin, which may raise systemic tretinoin levels and increase retinoid toxicity such as headache, pseudotumor cerebri and hypertriglyceridemia. Oral tretinoin is the main concern.
How serious is the interaction between Levoketoconazole and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for retinoid toxicity and intracranial hypertension signs; consider reducing the tretinoin dose if adverse effects appear.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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