Drug interactions
Levoketoconazole + Vinorelbine
Severity: Major
Levoketoconazole and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may considerably increase vinorelbine exposure. This raises the risk of severe neutropenia and neurotoxicity.
What this interaction means in plain words
Levoketoconazole and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levoketoconazole belongs to Endocrine; Vinorelbine belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces vinorelbine clearance.
What to do
Avoid the combination if possible, or monitor blood counts frequently and reduce the vinorelbine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Vinorelbine?
MediHelp rates the interaction as major. Levoketoconazole and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and may considerably increase vinorelbine exposure. This raises the risk of severe neutropenia and neurotoxicity.
How serious is the interaction between Levoketoconazole and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor blood counts frequently and reduce the vinorelbine dose.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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