Drug interactions
Levomilnacipran + Loxapine
Severity: Moderate
Levomilnacipran and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonin-norepinephrine reuptake inhibitor with an antipsychotic may increase the risk of serotonin syndrome and neuroleptic malignant syndrome. Levomilnacipran can also raise blood pressure and heart rate.
What this interaction means in plain words
Levomilnacipran and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic modulation; mechanism is largely pharmacodynamic.
What to do
Monitor for mental status change, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity, especially after dose changes. Stop one or both agents if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Loxapine?
MediHelp rates the interaction as moderate. Levomilnacipran and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonin-norepinephrine reuptake inhibitor with an antipsychotic may increase the risk of serotonin syndrome and neuroleptic malignant syndrome. Levomilnacipran can also raise blood pressure and heart rate.
How serious is the interaction between Levomilnacipran and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity, especially after dose changes. Stop one or both agents if serotonin syndrome or NMS is suspected.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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