Drug interactions
Levomilnacipran + Mifepristone
Severity: Moderate
Levomilnacipran and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise levomilnacipran exposure through CYP3A4 inhibition. Increased levels can cause more noradrenergic and serotonergic effects, such as hypertension, tachycardia and nausea.
What this interaction means in plain words
Levomilnacipran and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of levomilnacipran by mifepristone.
What to do
Limit the levomilnacipran dose to the label maximum with strong CYP3A4 inhibitors and monitor blood pressure and heart rate. Consider an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Mifepristone?
MediHelp rates the interaction as moderate. Levomilnacipran and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may raise levomilnacipran exposure through CYP3A4 inhibition. Increased levels can cause more noradrenergic and serotonergic effects, such as hypertension, tachycardia and nausea.
How serious is the interaction between Levomilnacipran and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the levomilnacipran dose to the label maximum with strong CYP3A4 inhibitors and monitor blood pressure and heart rate. Consider an alternative antidepressant.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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