Drug interactions
Levomilnacipran + Naratriptan
Severity: Moderate
Levomilnacipran and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with SNRIs carry a labeled warning for serotonin syndrome. Cases are uncommon but potentially severe.
What this interaction means in plain words
Levomilnacipran and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from triptan receptor agonism and inhibition of serotonin reuptake by levomilnacipran.
What to do
Counsel on serotonin syndrome symptoms and monitor closely after initiation or dose increases. Stop the serotonergic drugs if the syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Naratriptan?
MediHelp rates the interaction as moderate. Levomilnacipran and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with SNRIs carry a labeled warning for serotonin syndrome. Cases are uncommon but potentially severe.
How serious is the interaction between Levomilnacipran and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on serotonin syndrome symptoms and monitor closely after initiation or dose increases. Stop the serotonergic drugs if the syndrome is suspected.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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