Drug interactions
Levomilnacipran + Nicardipine
Severity: Minor
Levomilnacipran and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is partly metabolized by CYP3A4, and strong inhibitors raise its levels. Nicardipine is a weaker inhibitor, so the effect is likely small, though adverse effects such as raised blood pressure, nausea and heart rate increases could occur.
What this interaction means in plain words
Levomilnacipran and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levomilnacipran belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 metabolism of levomilnacipran by nicardipine.
What to do
No routine dose change is needed. Monitor blood pressure, heart rate and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Nicardipine?
MediHelp rates the interaction as minor. Levomilnacipran and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levomilnacipran is partly metabolized by CYP3A4, and strong inhibitors raise its levels. Nicardipine is a weaker inhibitor, so the effect is likely small, though adverse effects such as raised blood pressure, nausea and heart rate increases could occur.
How serious is the interaction between Levomilnacipran and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure, heart rate and tolerability.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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