Drug interactions
Levomilnacipran + Oxaprozin
Severity: Moderate
Levomilnacipran and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran, an SNRI, reduces platelet serotonin content and can impair platelet aggregation, while oxaprozin inhibits platelet function and damages the gastric mucosa. Combining them raises the risk of gastrointestinal and other bleeding, particularly in older patients or those on anticoagulants.
What this interaction means in plain words
Levomilnacipran and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet aggregation (serotonin depletion plus COX inhibition) with NSAID-related mucosal injury.
What to do
Monitor for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest time, or choose acetaminophen if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levomilnacipran and Oxaprozin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Oxaprozin?
MediHelp rates the interaction as moderate. Levomilnacipran and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran, an SNRI, reduces platelet serotonin content and can impair platelet aggregation, while oxaprozin inhibits platelet function and damages the gastric mucosa. Combining them raises the risk of gastrointestinal and other bleeding, particularly in older patients or those on anticoagulants.
How serious is the interaction between Levomilnacipran and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest time, or choose acetaminophen if appropriate.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
