Drug interactions
Levomilnacipran + Quetiapine
Severity: Moderate
Levomilnacipran and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic antidepressant with an antipsychotic may rarely lead to serotonin syndrome or neuroleptic malignant syndrome. Levomilnacipran can also raise blood pressure and heart rate, and quetiapine can cause orthostatic changes. The combination is common in practice and usually tolerated.
What this interaction means in plain words
Levomilnacipran and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic effects (serotonin and norepinephrine reuptake inhibition with D2 and 5-HT2A blockade).
What to do
Monitor for agitation, hyperthermia, rigidity, tremor and autonomic instability, especially after dose changes. Check blood pressure and heart rate periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Quetiapine?
MediHelp rates the interaction as moderate. Levomilnacipran and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonergic antidepressant with an antipsychotic may rarely lead to serotonin syndrome or neuroleptic malignant syndrome. Levomilnacipran can also raise blood pressure and heart rate, and quetiapine can cause orthostatic changes. The combination is common in practice and usually tolerated.
How serious is the interaction between Levomilnacipran and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, rigidity, tremor and autonomic instability, especially after dose changes. Check blood pressure and heart rate periodically.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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