Drug interactions
Levomilnacipran + Quinidine
Severity: Moderate
Levomilnacipran and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may raise levomilnacipran exposure through CYP3A4 inhibition. This may increase adverse effects such as hypertension, tachycardia and serotonergic effects.
What this interaction means in plain words
Levomilnacipran and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition reduces levomilnacipran metabolism.
What to do
Monitor blood pressure and heart rate and watch for adverse effects. Limit the levomilnacipran dose if inhibition is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Quinidine?
MediHelp rates the interaction as moderate. Levomilnacipran and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may raise levomilnacipran exposure through CYP3A4 inhibition. This may increase adverse effects such as hypertension, tachycardia and serotonergic effects.
How serious is the interaction between Levomilnacipran and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and watch for adverse effects. Limit the levomilnacipran dose if inhibition is significant.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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