Drug interactions
Levomilnacipran + Sumatriptan
Severity: Moderate
Levomilnacipran and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and combining it with a triptan can occasionally cause serotonin syndrome. Labeling for both drug classes warns about this risk.
What this interaction means in plain words
Levomilnacipran and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition and 5-HT1B/1D agonism.
What to do
Monitor for serotonin syndrome, particularly at initiation or dose increases, and instruct patients to report agitation, tremor, fever or diarrhea. Stop the serotonergic drugs if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Sumatriptan?
MediHelp rates the interaction as moderate. Levomilnacipran and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and combining it with a triptan can occasionally cause serotonin syndrome. Labeling for both drug classes warns about this risk.
How serious is the interaction between Levomilnacipran and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, particularly at initiation or dose increases, and instruct patients to report agitation, tremor, fever or diarrhea. Stop the serotonergic drugs if it develops.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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