Drug interactions
Levonorgestrel + Nevirapine
Severity: Moderate
Levonorgestrel and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower levonorgestrel concentrations, potentially reducing the efficacy of oral contraceptives or emergency contraception.
What this interaction means in plain words
Levonorgestrel and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, accelerating levonorgestrel metabolism.
What to do
Use an additional barrier method or a non-hormonal alternative. For emergency contraception, consider a copper IUD or a higher levonorgestrel dose per local guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Nevirapine?
MediHelp rates the interaction as moderate. Levonorgestrel and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can lower levonorgestrel concentrations, potentially reducing the efficacy of oral contraceptives or emergency contraception.
How serious is the interaction between Levonorgestrel and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional barrier method or a non-hormonal alternative. For emergency contraception, consider a copper IUD or a higher levonorgestrel dose per local guidance.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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