Drug interactions
Levonorgestrel + Omaveloxolone
Severity: Major
Levonorgestrel and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is a weak CYP3A4 inducer and may reduce the efficacy of systemically acting hormonal contraceptives. Reliability of pills, implants and similar products may be reduced.
What this interaction means in plain words
Levonorgestrel and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levonorgestrel belongs to Endocrine; Omaveloxolone belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases metabolism of levonorgestrel.
What to do
Use an alternative or additional non-hormonal contraceptive during treatment and for a period after stopping, per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levonorgestrel
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Levonorgestrel with Omaveloxolone?
MediHelp rates the interaction as major. Levonorgestrel and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omaveloxolone is a weak CYP3A4 inducer and may reduce the efficacy of systemically acting hormonal contraceptives. Reliability of pills, implants and similar products may be reduced.
How serious is the interaction between Levonorgestrel and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative or additional non-hormonal contraceptive during treatment and for a period after stopping, per labeling.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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