Drug interactions
Levonorgestrel + Pretomanid
Severity: Minor
Levonorgestrel and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with hepatotoxicity, and other potentially hepatotoxic agents add to the concern. Levonorgestrel has low hepatotoxic potential, so the added risk is small.
What this interaction means in plain words
Levonorgestrel and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible additive hepatotoxicity; no specific mechanism is established.
What to do
Monitor liver function during the pretomanid regimen and review any symptoms of hepatic injury.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Pretomanid
Frequently asked questions
Can I take Levonorgestrel with Pretomanid?
MediHelp rates the interaction as minor. Levonorgestrel and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid-containing regimens are associated with hepatotoxicity, and other potentially hepatotoxic agents add to the concern. Levonorgestrel has low hepatotoxic potential, so the added risk is small.
How serious is the interaction between Levonorgestrel and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function during the pretomanid regimen and review any symptoms of hepatic injury.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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