Drug interactions
Levonorgestrel + Repotrectinib
Severity: Major
Levonorgestrel and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib can lower progestin exposure enough to reduce the effectiveness of hormonal contraceptives. Pregnancy during therapy carries fetal risk.
What this interaction means in plain words
Levonorgestrel and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Levonorgestrel belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induces CYP3A4, increasing levonorgestrel metabolism.
What to do
Use an effective non-hormonal contraceptive during treatment and for the labeled period afterward.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levonorgestrel
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Levonorgestrel with Repotrectinib?
MediHelp rates the interaction as major. Levonorgestrel and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib can lower progestin exposure enough to reduce the effectiveness of hormonal contraceptives. Pregnancy during therapy carries fetal risk.
How serious is the interaction between Levonorgestrel and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive during treatment and for the labeled period afterward.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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