Drug interactions
Levonorgestrel + Rucaparib
Severity: Minor
Levonorgestrel and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and could modestly raise levonorgestrel exposure. The expected clinical effect is small, since levonorgestrel has a wide therapeutic margin.
What this interaction means in plain words
Levonorgestrel and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of levonorgestrel by rucaparib.
What to do
No routine dose change is needed; monitor for progestogenic adverse effects such as breakthrough bleeding or nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Levonorgestrel with Rucaparib?
MediHelp rates the interaction as minor. Levonorgestrel and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and could modestly raise levonorgestrel exposure. The expected clinical effect is small, since levonorgestrel has a wide therapeutic margin.
How serious is the interaction between Levonorgestrel and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for progestogenic adverse effects such as breakthrough bleeding or nausea.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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