Drug interactions
Levonorgestrel + Siltuximab
Severity: Minor
Levonorgestrel and Siltuximab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-6 with siltuximab can restore CYP450 activity that was suppressed by inflammation, which could lower levonorgestrel concentrations. This is a theoretical concern and is more relevant to narrow-therapeutic-index drugs.
What this interaction means in plain words
Levonorgestrel and Siltuximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Siltuximab belongs to Miscellaneous.
Why it happens
IL-6 inhibition normalizes suppressed CYP3A4 expression, potentially increasing levonorgestrel clearance.
What to do
No routine adjustment is needed; consider a backup contraceptive method if breakthrough bleeding occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Levonorgestrel with Siltuximab?
MediHelp rates the interaction as minor. Levonorgestrel and Siltuximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Blocking IL-6 with siltuximab can restore CYP450 activity that was suppressed by inflammation, which could lower levonorgestrel concentrations. This is a theoretical concern and is more relevant to narrow-therapeutic-index drugs.
How serious is the interaction between Levonorgestrel and Siltuximab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; consider a backup contraceptive method if breakthrough bleeding occurs.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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